Antimycobacterial and antitumor activities of Palladium(II) complexes containing isonicotinamide (isn): X-ray structure of trans-[Pd(N(3))(2)(isn)(2)]
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
20/10/2012
20/10/2012
2010
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Resumo |
Complexes of the type trans-[PdX(2)(isn)(2)] {X = Cl (1), N(3) (2), SCN (3), NCO (4); isn = isonicotinamide} were synthesized and evaluated for in vitro antimycobacterial and antitumor activities. The coordination mode of the isonicotinamide and the pseudohalide ligands was inferred by IR spectroscopy. Single crystal X-ray diffraction determination on 2 showed that coordination geometry around Pd(II) is nearly square planar, with the ligands in a trans configuration. All the compounds demonstrated better in vitro activity against Mycobacterium tuberculosis than isonicotinamide and pyrazinamide. Among the complexes, compound 2 was found to be the most active with MIC of 35.89 mu M. Complexes 1-4 were also screened for their in vitro antitumor activity towards LM3 and LP07 murine cancer cell lines. (C) 2010 Elsevier Masson SAS. All rights reserved. CAPES Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) CNPq Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) FAPESP |
Identificador |
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.45, n.11, p.4863-4868, 2010 0223-5234 http://producao.usp.br/handle/BDPI/30092 10.1016/j.ejmech.2010.07.057 |
Idioma(s) |
eng |
Publicador |
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
Relação |
European Journal of Medicinal Chemistry |
Direitos |
restrictedAccess Copyright ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
Palavras-Chave | #Palladium(II) complexes #Isonicotinamide #Cytotoxicity assays #Antimycobacterial #Antitumor activity #METAL-COMPLEXES #MOLECULAR-STRUCTURE #IN-VITRO #COORDINATION POLYMERS #PYRAZOLYL COMPLEXES #CRYSTAL-STRUCTURE #PD(II) COMPLEXES #HALIDE-COMPLEXES #TUBERCULOSIS #LIGANDS #Chemistry, Medicinal |
Tipo |
article original article publishedVersion |