Electrospinning of Hyperbranched Poly-L-Lysine/Polyaniline Nanofibers for Application in Cardiac Tissue Engineering
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
20/10/2012
20/10/2012
2010
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Resumo |
Electrospun polyaniline nanofibers are one of the most promising materials for cardiac tissue engineering due to their tunable electroactive properties. Moreover, the biocompatibility of polyaniline nanofibes can be improved by grafting of adhesive peptides during the synthesis. In this paper, we describe the biocompatible properties and cardiomyocytes proliferation on polyaniline electrospun nanofibers modified by hyperbranched poly-L-lysine dendrimers (HPLys). The microstructure characterization of the HPLys/polyaniline nanofibers was carried out by scanning electron microscopy (SEM). It was observed that the application of electrical current stimulates the differentiation of cardiac cells cultured on the nanofiber scaffolds. Both electroactivity and biocompatibility of the HPLys based nanofibers suggest the use this material for culture of cardiac cells and opens the possibility of using this material as a biocompatible electroactive 3-D matrix in cardiac tissue engineering. |
Identificador |
JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY, v.47, n.12, p.1203-1207, 2010 1060-1325 http://producao.usp.br/handle/BDPI/29902 10.1080/10601325.2010.518847 |
Idioma(s) |
eng |
Publicador |
TAYLOR & FRANCIS INC |
Relação |
Journal of Macromolecular Science Part A-pure and Applied Chemistry |
Direitos |
restrictedAccess Copyright TAYLOR & FRANCIS INC |
Palavras-Chave | #Tissue engineering #hyperbranched poly-l-lysine #polyaniline nanotubes #conductive electrospun nanofibers #ELECTRICAL-STIMULATION #VENTRICULAR MYOCYTES #SCAFFOLD #CULTURE #Polymer Science |
Tipo |
article proceedings paper publishedVersion |