Application of computed tomography images in the evaluation of magnetic nanoparticles biodistribution
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
20/10/2012
20/10/2012
2010
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| Resumo |
In this work we evaluate the effectiveness of computed tomography images as a tool to determine magnetic nanoparticle biodistribution over biological tissues. For this purpose, tomography images for magnetic nanoparticles, composed of Fe(3)O(4), coated with 2,3-dimercaptosuccinic acid (DMSA), were generated at several material concentrations. The comparison of CT numbers, calculated from these images generated at clinical conditions, with typical CT numbers for biological tissues, shows that the detection of nanoparticle in most tissues is only possible for high material concentrations. (C) 2010 Elsevier B.V. All rights reserved. Brazilian Agency CNPq[150219/2009-1] Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Brazilian Agency CNPq[307095/2008-8] |
| Identificador |
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, v.322, n.16, p.2405-2407, 2010 0304-8853 http://producao.usp.br/handle/BDPI/29464 10.1016/j.jmmm.2010.02.046 |
| Idioma(s) |
eng |
| Publicador |
ELSEVIER SCIENCE BV |
| Relação |
Journal of Magnetism and Magnetic Materials |
| Direitos |
restrictedAccess Copyright ELSEVIER SCIENCE BV |
| Palavras-Chave | #Magnetic nanoparticle #Computed tomography #Imaging contrast #Iodine #Materials Science, Multidisciplinary #Physics, Condensed Matter |
| Tipo |
article original article publishedVersion |
