Tissue response around silicon nitride implants in rabbits


Autoria(s): SILVA, Cecilia C. Guedes e; KONIG JR., Bruno; CARBONARI, Marcelo Jose; YOSHIMOTO, Marcelo; ALLEGRINI JR., Sergio; BRESSIANI, Jose Carlos
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

20/10/2012

20/10/2012

2008

Resumo

The chemical and dimensional stability associated with suitable fracture toughness and propitious tribological characteristics make silicon nitride-based ceramics potential candidates for biomedical applications, mainly as orthopedic implants. Considering this combination of properties, silicon nitride components were investigated in relation to their biocompatibility. For this study, two cylindrical implants were installed in each tibia of five rabbits and were kept in the animals for 8 weeks. During the healing time, tissue tracers were administrated in the animals so as to evaluate the bone growth around the implants. Eight weeks after the surgery, the animals were euthanized and histological analyses were performed. No adverse reactions were observed close to the implant. The osteogenesis process occurred during the entire period defined by the tracers. However, this process occurred more intensely 4 weeks after the surgery. In addition, the histological analyses showed that bone growth occurred preferentially in the cortical areas. Different kinds of tissue were identified on the implant surface, characterized by lamellar bone tissue containing osteocytes and osteons, by a noncalcified matrix containing osteoblasts, or by the presence of collagen III, which may change to collagen I or remain as a fibrous tissue. The results demonstrated that silicon nitride obtained according to the procedure proposed in this research is a biocompatible material. (c) 2007 Wiley Periodicals, Inc.

Identificador

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, v.84A, n.2, p.337-343, 2008

1549-3296

http://producao.usp.br/handle/BDPI/28639

10.1002/jbm.a.31363

http://dx.doi.org/10.1002/jbm.a.31363

Idioma(s)

eng

Publicador

WILEY-LISS

Relação

Journal of Biomedical Materials Research Part A

Direitos

restrictedAccess

Copyright WILEY-LISS

Palavras-Chave #silicon nitride #biocompatibility #in vivo tests #MICROSCOPIC OBSERVATIONS #SINGLE OSTEONS #CORTICAL BONE #FEMORAL-HEAD #CERAMICS #LIGHT #PROSTHESES #CELLS #Engineering, Biomedical #Materials Science, Biomaterials
Tipo

article

original article

publishedVersion