In Vitro Activity of the Antifungal Plant Defensin RsAFP2 against Candida Isolates and Its In Vivo Efficacy in Prophylactic Murine Models of Candidiasis
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
20/10/2012
20/10/2012
2008
|
| Resumo |
We show that RsAFP2, a plant defensin that interacts with fungal glucosylceramides, is active against Candida albicans, inhibits to a lesser extent other Candida species, and is nontoxic to mammalian cells. Moreover, glucosylceramide levels in Candida species correlate with RsAFP2 sensitivity. We found RsAFP2 prophylactically effective against murine candidiasis. Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ) International Society for Infectious Diseases (ISID) International Society for Infectious Diseases (ISID) FWO-Vlaanderen, Belgium FWO-Vlaanderen, Belgium K. U. Leuven K. U. Leuven |
| Identificador |
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, v.52, n.12, p.4522-4525, 2008 0066-4804 http://producao.usp.br/handle/BDPI/28595 10.1128/AAC.00448-08 |
| Idioma(s) |
eng |
| Publicador |
AMER SOC MICROBIOLOGY |
| Relação |
Antimicrobial Agents and Chemotherapy |
| Direitos |
restrictedAccess Copyright AMER SOC MICROBIOLOGY |
| Palavras-Chave | #CRYPTOCOCCUS-NEOFORMANS #GLUCOSYLCERAMIDE SYNTHASE #BIOLOGICAL FUNCTIONS #MONOCLONAL-ANTIBODY #ALBICANS INFECTION #FONSECAEA-PEDROSOI #RAPHANUS-SATIVUS #GROWTH #PATHOGENICITY #GLYCOSPHINGOLIPIDS #Microbiology #Pharmacology & Pharmacy |
| Tipo |
article original article publishedVersion |
