Myeloperoxidase as Inflammatory Marker of Periodontal Disease: Experimental Study in Rats
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
20/10/2012
20/10/2012
2009
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Resumo |
Rationale: Previous studies have used myeloperoxidase (MPO) as an inflammatory marker to estimate the accumulation of neutrophils in inflamed regions. Objective: The aim of this experimental study was to quantify the levels of MPO related to experimental periodontal disease in rats. Methods: Periodontal disease was induced in a group of rats using placement of a ligature around molar teeth. A group of rats without ligature placement served as a control. Measurements were made on the 3rd, 7th, 15th and 30th day from baseline. Gingival tissues were taken for quantification of MPO levels by ELISA. Results: The rats with induced periodontal disease showed statistically higher MPO levels (p 0.05) when compared to control rats. A significant increase in the levels of MPO released on days 7 and 30 was observed, with higher levels in the group with induced periodontitis. Conclusion: The levels of MPO were found to be higher in rats with induced periodontal disease, confirming the hypothesis that MPO may serve as an inflammatory marker for periodontitis. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) FAPESP (Research Foundation of the State of Sao Paulo)[04/09849-0] Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) CAPES |
Identificador |
IMMUNOLOGICAL INVESTIGATIONS, v.38, n.2, p.117-122, 2009 0882-0139 http://producao.usp.br/handle/BDPI/28588 10.1080/08820130802457503 |
Idioma(s) |
eng |
Publicador |
TAYLOR & FRANCIS INC |
Relação |
Immunological Investigations |
Direitos |
restrictedAccess Copyright TAYLOR & FRANCIS INC |
Palavras-Chave | #Periodontal diseases #Inflammation #Peroxidase #Enzymes #GINGIVAL CREVICULAR FLUID #PEROXIDASE #ACTIVATION #HEALTH #Immunology |
Tipo |
article original article publishedVersion |