Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
20/10/2012
20/10/2012
2010
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| Resumo |
The synthesis and in vitro activity of R(+)-Limonene derivatives against Leishmania and Trypanosoma cruzi strains are reported. Seven compounds have shown better in vitro activity against Leishmania (V.)braziliensis than the standard drug pentamidine. Additionally, we have identified two promising new anti-T. cruzi limonene derivatives. (C) 2010 Elsevier Masson SAS. All rights reserved. Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) CAPES/MEC CNPq[MCT/CNPq 02/2006] Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) CNPq[MCT/CNPq 14/2008] Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) FAPESP |
| Identificador |
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.45, n.4, p.1524-1528, 2010 0223-5234 http://producao.usp.br/handle/BDPI/28498 10.1016/j.ejmech.2009.12.061 |
| Idioma(s) |
eng |
| Publicador |
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| Relação |
European Journal of Medicinal Chemistry |
| Direitos |
restrictedAccess Copyright ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| Palavras-Chave | #Limonene #Leishmania #Trypanosoma cruzi #Anti-parasitic activity #Hydroaminomethylation #AMINO ALCOHOL DERIVATIVES #PARASITIC DISEASES #ESSENTIAL OILS #CHEMOTHERAPY #OXIDE #Chemistry, Medicinal |
| Tipo |
article original article publishedVersion |
