Microbiological profile of untreated subjects with localized aggressive periodontitis


Autoria(s): FAVERI, Marcelo; FIGUEIREDO, Luciene Cristina; DUARTE, Poliana Mendes; MESTNIK, Maria Josefa; MAYER, Marcia Pinto Alves; FERES, Magda
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

20/10/2012

20/10/2012

2009

Resumo

Aim The microbial profile of localized aggressive periodontitis (LAgP) has not yet been determined. Therefore, the aim of this study was to evaluate the subgingival microbial composition of LAgP. Material and Methods One hundred and twenty subjects with LAgP (n=15), generalized aggressive periodontitis (GAgP, n=25), chronic periodontitis (ChP, n=30) or periodontal health (PH, n=50) underwent clinical and microbiological assessment. Nine subgingival plaque samples were collected from each subject and analysed for their content of 38 bacterial species using checkerboard DNA-DNA hybridization. Results Red complex and some orange complex species are the most numerous and prevalent periodontal pathogens in LAgP. The proportions of Aggregatibacter actinomycetemcomitans were elevated in shallow and intermediate pockets of LAgP subjects in comparison with those with GAgP or ChP, but not in deep sites. This species also showed a negative correlation with age and with the proportions of red complex pathogens. The host-compatible Actinomyces species were reduced in LAgP. Conclusion A. actinomycetemcomitans seems to be associated with the onset of LAgP, and Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Campylobacter gracilis, Eubacterium nodatum and Prevotella intermedia play an important role in disease progression. Successful treatment of LAgP would involve a reduction in these pathogens and an increase in the Actinomyces species.

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Fundacao de Amparo Pesquisa do Estado de Sao Paulo (FAPESP, Brazil)[2006/52890-6]

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Fundacao de Amparo Pesquisa do Estado de Sao Paulo (FAPESP, Brazil)[2005/59443-2]

U.S. National Institutes of Health (NIH)

National Institutes of Health (NIH, USA)[5 R03 TW006269-02]

Identificador

JOURNAL OF CLINICAL PERIODONTOLOGY, v.36, n.9, p.739-749, 2009

0303-6979

http://producao.usp.br/handle/BDPI/28448

10.1111/j.1600-051X.2009.01449.x

http://dx.doi.org/10.1111/j.1600-051X.2009.01449.x

Idioma(s)

eng

Publicador

WILEY-BLACKWELL PUBLISHING, INC

Relação

Journal of Clinical Periodontology

Direitos

restrictedAccess

Copyright WILEY-BLACKWELL PUBLISHING, INC

Palavras-Chave #DNA probe #localized aggressive periodontitis #microbiology #periodontal disease #subgingival microbiota #EARLY-ONSET PERIODONTITIS #ACTINOBACILLUS-ACTINOMYCETEMCOMITANS #JUVENILE PERIODONTITIS #SUBGINGIVAL MICROBIOTA #PERIODONTOPATHIC BACTERIA #PROGRESSIVE PERIODONTITIS #BACTEROIDES-INTERMEDIUS #LONGITUDINAL COHORT #DISEASE #POPULATION #Dentistry, Oral Surgery & Medicine
Tipo

article

original article

publishedVersion