Evolutionary history of Dengue virus type 4: Insights into genotype phylodynamics
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
20/10/2012
20/10/2012
2011
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Resumo |
Dengue virus type 4 (DENV-4) circulates in tropical and subtropical countries from Asia and the Americas. Despite the importance of dengue virus distribution, little is known about the worldwide viral spread. Following a Bayesian phylogenetic approach we inferred the evolutionary history of 310 isolates sampled from 37 countries during the time period 1956-2008 and the spreading dynamics for genotypes I and II. The region (tropical rainforest biome) comprised by Malaysia-Thailand was the most likely ancestral area from which the serotype has originated and spread. Interestingly, cross-correlation analysis on demographic time series with the Asian sequences showed a statistically significant negative correlation that could be suggestive of competition among genotypes within the same serotype. (C) 2011 Elsevier B.V. All rights reserved. FAPESP[2008/10713-6] Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) CAPES Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) CNPq - PQ |
Identificador |
INFECTION GENETICS AND EVOLUTION, v.11, n.5, p.878-885, 2011 1567-1348 http://producao.usp.br/handle/BDPI/28365 10.1016/j.meegid.2011.02.007 |
Idioma(s) |
eng |
Publicador |
ELSEVIER SCIENCE BV |
Relação |
Infection Genetics and Evolution |
Direitos |
restrictedAccess Copyright ELSEVIER SCIENCE BV |
Palavras-Chave | #Dengue virus type 4 #Evolution #Phylogeography #Phylodynamics #HEMORRHAGIC-FEVER #MOLECULAR EVOLUTION #SEROTYPE 4 #PHYLOGENY #INFECTION #DYNAMICS #EPIDEMIOLOGY #ANTIBODIES #SELECTION #THAILAND #Infectious Diseases |
Tipo |
article original article publishedVersion |