Effects of cyclooxygenase inhibitors on parasite burden, anemia and oxidative stress in murine Trypanosoma cruzi infection


Autoria(s): TATAKIHARA, Vera L. Hideko; CECCHINI, Rubens; BORGES, Celso L.; MALVEZI, Aparecida D.; SOUZA, Viviane K. Graca-de; YAMADA-OGATTA, Sueli F.; RIZZO, Luiz V.; PINGE-FILHO, Phileno
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

20/10/2012

20/10/2012

2008

Resumo

Prostaglandins are known to be produced by macrophages when challenged with Trypanosoma cruzi, the etiological agent of Chagas` disease. It is not known whether these lipid mediators play a role in oxidative stress in host defenses against this important protozoan parasite. In this study, we demonstrated that inducible cyclooxygenase-mediated prostaglandin production is a key chemical mediator in the control of parasite burden and erythrocyte oxidative stress during T. cruzi infection in C57BL/6 and BALB/c mice, prototype hosts for the study of resistance and susceptibility in murine Chagas` disease. The results suggested the existence of at least two mechanisms of oxidative stress, dependent or independent with regard to the nitric oxide and cyclooxygenase pathway, where one or the other is more evident depending on the mouse strain.

Identificador

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, v.52, n.1, p.47-58, 2008

0928-8244

http://producao.usp.br/handle/BDPI/28240

10.1111/j.1574-695X.2007.00340.x

http://dx.doi.org/10.1111/j.1574-695X.2007.00340.x

Idioma(s)

eng

Publicador

BLACKWELL PUBLISHING

Relação

Fems Immunology and Medical Microbiology

Direitos

restrictedAccess

Copyright BLACKWELL PUBLISHING

Palavras-Chave #Trypanosoma cruzi #Chagas` disease #cyclooxygenase #anemia #oxidative stress #nitric oxide #NONSTEROIDAL ANTIINFLAMMATORY DRUGS #RED-BLOOD-CELLS #NITRIC-OXIDE #CHAGAS-DISEASE #INDUCIBLE CYCLOOXYGENASE #SUSCEPTIBLE MICE #BALB/C MICE #MACROPHAGES #CARDIOMYOPATHY #DYSFUNCTION #Immunology #Infectious Diseases #Microbiology
Tipo

article

original article

publishedVersion