Hyaluronidase increases the duration of mepivacaine in inferior alveolar nerve blocks
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
---|---|
Data(s) |
20/10/2012
20/10/2012
2008
|
Resumo |
Purpose: To evaluate the duration of the effect of mepivacaine when hyaluronidase is injected immediately prior to the end of pulpal anesthesia. Patients and Methods: Forty bilateral, symmetrical third molar surgeries were performed in 20 healthy patients. Inferior alveolar nerve block was induced using 2.8 mL 2% mepivacaine with epinephrine. Hyaluronidase (75 turbidity-reducing units) or a placebo was injected 40 minutes after the beginning of pulpar anesthesia (randomized and double-blind trial). The duration of effect in the pulpal and gingival tissues was evaluated by response to painful electrical stimuli applied to the Adjacent premolar, and by mechanical stimuli (pin prick) to the vestibular gingiva, respectively. Results: in both tissues, the duration of anesthetic effect with hyaluronidase was longer (P <.01) than with the placebo. Conclusion: Hyaluronidase increases the duration of mepivacaine in inferior alveolar nerve blocks. (c) 2008 American Association of Oral and Maxillofacial Surgeons. |
Identificador |
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, v.66, n.2, p.286-290, 2008 0278-2391 http://producao.usp.br/handle/BDPI/28226 10.1016/j.joms.2007.06.628 |
Idioma(s) |
eng |
Publicador |
W B SAUNDERS CO-ELSEVIER INC |
Relação |
Journal of Oral and Maxillofacial Surgery |
Direitos |
restrictedAccess Copyright W B SAUNDERS CO-ELSEVIER INC |
Palavras-Chave | #ANESTHESIA #Dentistry, Oral Surgery & Medicine |
Tipo |
article original article publishedVersion |