Neurofilament heavy subunit in cerebrospinal fluid: A biomarker of amyotrophic lateral sclerosis?
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
20/10/2012
20/10/2012
2011
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| Resumo |
The objectives of this study were to investigate the presence of the three neurofilament subunits, ubiquitin, proteasome and 3-nitrotyrosine, in CSF samples of ALS patients. CSF samples were obtained by lumbar puncture from 10 ALS patients and six controls. All samples were analysed by Western blotting. Results revealed that neurofilament heavy subunit was identified in 70% of ALS cases and we conclude that this subunit may be a promising biomarker for clinical diagnosis of ALS. Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) FAPERJ CNPq Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) CAPES Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) FUJB FUJB |
| Identificador |
AMYOTROPHIC LATERAL SCLEROSIS, v.12, n.2, p.144-147, 2011 1748-2968 http://producao.usp.br/handle/BDPI/28145 10.3109/17482968.2010.542002 |
| Idioma(s) |
eng |
| Publicador |
INFORMA HEALTHCARE |
| Relação |
Amyotrophic Lateral Sclerosis |
| Direitos |
restrictedAccess Copyright INFORMA HEALTHCARE |
| Palavras-Chave | #Amyotrophic Lateral Sclerosis #cerebrospinal fluid #proteinopathy #protein aggregation and neurofilament #MOTOR-NEURONS #SPINAL-CORDS #PROTEASOME #UBIQUITIN #ALS #Clinical Neurology |
| Tipo |
article original article publishedVersion |
