Effects of hyperbaric oxygen therapy on facial nerve regeneration
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
20/10/2012
20/10/2012
2008
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Resumo |
Conclusion. Hyperbaric oxygen treatment (HBOT) promoted an increase of the mean axonal diameter in the group evaluated 2 weeks after lesion induction, which suggests a more advanced regeneration process. However, the number of myelin nerve fibers of the facial nerve of the rabbits was similar when compared to the control and treatment groups, in both evaluation periods. Objective. To evaluate the effect of HBOT on the histological pattern of the facial nerve in rabbits exposed to a nerve crush injury. Materials and methods. Twenty rabbits were exposed to facial nerve crush injury. Ten rabbits received HBOT, 10 rabbits comprised the control group. The rabbits were sacrificed 2 and 4 weeks after the trauma. Qualitative morphological analysis, measurement of the external axonal diameters and myelin fiber count were carried out in an area of 185 000 mu m(2). Results. There was an increase in the area of the axons and thicker myelin in the 2 weeks treatment group in comparison with the control group. The mean diameter of the axons was of 2.34 mu m in the control group and of 2.81 mu m in the HBOT group, with statistically significant differences. The 2 week control group had a mean number of myelin fibers of 186 +/- 5.2664, and the HBOT group had a mean number of 2026.3 +/- 302; this was not statistically significant. The 4 week control group presented a mean of 2495.1 +/- 479 fibers and the HBOT group presented a mean of 2359.9 +/- 473; this was not statistically significant. |
Identificador |
ACTA OTO-LARYNGOLOGICA, v.128, n.9, p.1048-1052, 2008 0001-6489 http://producao.usp.br/handle/BDPI/28136 10.1080/00016480701827525 |
Idioma(s) |
eng |
Publicador |
INFORMA HEALTHCARE |
Relação |
Acta Oto-laryngologica |
Direitos |
restrictedAccess Copyright INFORMA HEALTHCARE |
Palavras-Chave | #facial nerve #hyperbaric oxygenation #nerve regeneration #rabbits #INJURY #ISCHEMIA #RABBITS #NEUROPATHY #Otorhinolaryngology |
Tipo |
article original article publishedVersion |