Beneficial Effects of Physical Training on the Cardio-Inflammatory Disorder Induced by Lung Ischemia/Reperfusion in Rats


Autoria(s): DELBIN, Maria Andreia; DAVEL, Ana Paula Couto; ROSSONI, Luciana Venturini; ANTUNES, Edson; ZANESCO, Angelina
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

20/10/2012

20/10/2012

2011

Resumo

Our laboratory demonstrated that training program attenuated the inflammatory responses in lung ischemia/reperfusion (IR). Considering the importance of the inflammatory responses on the cardiovascular system, we evaluate the effect of physical training on the vascular responsiveness and its underlying mechanism after lung IR. Male Wistar rats were submitted to run training and lung IR. Concentration-response curves for relaxing and contracting agents were obtained. Protein expressions of SOD-1 and p47(phox), plasma nitritre/nitrate (NO (x) (-) ) and interleukin 6 (IL-6) were evaluated. A decreased in the potency for acetylcholine and phenylephrine associated with an upregulation of the p47(phox) expression were found after Lung IR as well as an increase in IL-6 and NO (x) (-) levels. Run training attenuated the vascular dysfunction that was accompanied by reduction of the p47(phox) protein expression and IL-6 levels. Our findings show the beneficial effect of training on the vascular function that was associated with reduction in inflammatory response in lung IR.

Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Identificador

INFLAMMATION, v.34, n.5, p.319-325, 2011

0360-3997

http://producao.usp.br/handle/BDPI/28025

10.1007/s10753-010-9237-9

http://dx.doi.org/10.1007/s10753-010-9237-9

Idioma(s)

eng

Publicador

SPRINGER/PLENUM PUBLISHERS

Relação

Inflammation

Direitos

restrictedAccess

Copyright SPRINGER/PLENUM PUBLISHERS

Palavras-Chave #physical training #vascular dysfunction #inflammatory responses #lung ischemia/reperfusion #REPERFUSION INJURY #ISCHEMIA-REPERFUSION #VASCULAR REACTIVITY #RELAXATION RESPONSE #CORPUS CAVERNOSUM #EXERCISE #DYSFUNCTION #SURGERY #HYPERTENSION #EXPRESSION #Cell Biology #Immunology
Tipo

article

original article

publishedVersion