Amino acids and diabetes: implications for endocrine, metabolic and immune function
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
20/10/2012
20/10/2012
2011
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| Resumo |
Aberrant alterations in glucose and lipid concentrations and their pathways of metabolism are a hallmark of diabetes. However, much less is known about alterations in concentrations of amino acids and their pathways of metabolism in diabetes. In this review we have attempted to highlight, integrate and discuss common alterations in amino acid metabolism in a wide variety of cells and tissues and relate these changes to alterations in endocrine, physiologic and immune function in diabetes. Health Research Board of Ireland Health Research Board of Ireland Enterprise Ireland Enterprise Ireland Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) State of Sao Paulo Research Foundation (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Programme for support for centres of excellence PRONEX National Council for Scientific and Technological Development (CNPq), Brazil Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) |
| Identificador |
Frontiers in Bioscience, v.16, p.315-339, 2011 1093-9946 http://producao.usp.br/handle/BDPI/27997 10.2741/3690 |
| Idioma(s) |
eng |
| Publicador |
FRONTIERS IN BIOSCIENCE INC |
| Relação |
Frontiers in Bioscience |
| Direitos |
restrictedAccess Copyright FRONTIERS IN BIOSCIENCE INC |
| Palavras-Chave | #Amino acids #Alpha Cells #Beta Cells #Vascular Endothelial Cells #Skeletal Muscle #Liver #Immune Cells #Diabetes #Insulin Secretion #Metabolism #NADPH oxidase #Reactive Oxygen Species #Review #PANCREATIC BETA-CELLS #INDUCED INSULIN-SECRETION #L-ARGININE SUPPLEMENTATION #NITRIC-OXIDE SYNTHESIS #ORAL L-ARGININE #ENDOTHELIUM-DEPENDENT RELAXATION #RAT MESENTERIC LYMPHOCYTES #TOTAL HOMOCYSTEINE LEVELS #K-ATP-CHANNELS #NF-KAPPA-B #Biochemistry & Molecular Biology #Cell Biology |
| Tipo |
article original article publishedVersion |
