Angiotensin II induces superoxide generation via NAD(P)H oxidase activation in isolated rat pancreatic islets
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
20/10/2012
20/10/2012
2009
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| Resumo |
Angiotensin II (Ang II) controls blood pressure, electrolyte balance, cell growth and vascular remodeling. Ang II activates NAD(P)H oxidase in several tissues with important function in the control of insulin secretion. Considering the concomitant occurrence of hypertension, insulin resistance and pancreatic B cell secretion impairment in the development of type II diabetes the aim of the present study was to evaluate the effect of ANG II on NAD(P)H oxidase activation in isolated pancreatic islets. We found that ANGII-induced superoxide generation via NAD(P)H oxidase activation and increased protein and mRNA levels of NAD(P)H oxidase subunits (p47(PHOX) and gp91(PHOX)). (C) 2008 Elsevier B.V. All rights reserved. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) State of Sao Paulo Research Foundation (FAPESP) National Council for Scientific and Technological Development (CNPq), Brazil Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) |
| Identificador |
REGULATORY PEPTIDES, v.153, n.1/Mar, p.1-6, 2009 0167-0115 http://producao.usp.br/handle/BDPI/27913 10.1016/j.regpep.2008.11.004 |
| Idioma(s) |
eng |
| Publicador |
ELSEVIER SCIENCE BV |
| Relação |
Regulatory Peptides |
| Direitos |
restrictedAccess Copyright ELSEVIER SCIENCE BV |
| Palavras-Chave | #Angiotensin II #Isolated islets #NAD(P)H oxidase #END-POINT REDUCTION #BETA-CELL #OXIDATIVE STRESS #CARDIOVASCULAR MORBIDITY #DIABETIC COMPLICATIONS #GLUTATHIONE-PEROXIDASE #LOSARTAN INTERVENTION #VASCULAR CELLS #BLOOD-PRESSURE #NADPH OXIDASE #Endocrinology & Metabolism #Physiology |
| Tipo |
article original article publishedVersion |
