Chronic resistance training decreases MuRF-1 and Atrogin-1 gene expression but does not modify Akt, GSK-3 beta and p70S6K levels in rats
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
20/10/2012
20/10/2012
2009
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Resumo |
Long-term adaptation to resistance training is probably due to the cumulative molecular effects of each exercise session. Therefore, we studied in female Wistar rats the molecular effects of a chronic resistance training regimen (3 months) leading to skeletal muscle hypertrophy in the plantaris muscle. Our results demonstrated that muscle proteolytic genes MuRF-1 and Atrogin-1 were significantly decreased in the exercised group measured 24 h after the last resistance exercise session (41.64 and 61.19%, respectively; P < 0.05). Nonetheless, when measured at the same time point, 4EBP-1, GSK-3 beta and eIF2B epsilon mRNA levels and Akt, GSK-3 beta and p70S6K protein levels (regulators of translation initiation) were not modified. Such data suggests that if gene transcription constitutes a control point in the protein synthesis pathway this regulation probably occurs in early adaptation periods or during extreme situations leading to skeletal muscle remodeling. However, proteolytic gene expression is modified even after a prolonged resistance training regimen leading to moderate skeletal muscle hypertrophy. Brazilian Funding Agency (FAPESP-Fundacao de Amparo a Pesquisa do Estado de Sao Paulo)[08/51090-1] Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) |
Identificador |
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, v.106, n.3, p.415-423, 2009 1439-6319 http://producao.usp.br/handle/BDPI/27902 10.1007/s00421-009-1033-6 |
Idioma(s) |
eng |
Publicador |
SPRINGER |
Relação |
European Journal of Applied Physiology |
Direitos |
restrictedAccess Copyright SPRINGER |
Palavras-Chave | #Hypertrophy #Protein synthesis #Proteolysis #Skeletal muscle #HUMAN SKELETAL-MUSCLE #MESSENGER-RNA EXPRESSION #WEIGHT-LIFTING EXERCISE #TIME-COURSE #MYOTUBE HYPERTROPHY #MOLECULAR RESPONSES #PROTEIN-SYNTHESIS #HINDLIMB MUSCLES #M-LINE #ATROPHY #Physiology #Sport Sciences |
Tipo |
article original article publishedVersion |