Involvement of the AT(1) receptor in the venoconstriction induced by angiotensin II in both the inferior vena cava and femoral vein


Autoria(s): SILVA, Osmar Gomes da; ROSSIGNOLI, Patricia de Souza; CARRILLO-SEPULVEDA, Maria Alicia; BARRETO-CHAVES, Maria Luiza Morais; CHIES, Agnaldo Bruno
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

20/10/2012

20/10/2012

2011

Resumo

Although angiotensin II-induced venoconstriction has been demonstrated in the rat vena cava and femoral vein, the angiotensin II receptor subtypes (AT(1) or AT(2)) that mediate this phenomenon have not been precisely characterized. Therefore, the present study aimed to characterize the pharmacological receptors involved in the angiotensin II-induced constriction of rat venae cavae and femoral veins, as well as the opposing effects exerted by locally produced prostanoids and NO upon induction of these vasomotor responses. The obtained results suggest that both AT(1) and AT(2) angiotensin II receptors are expressed in both veins. Angiotensin II concentration-response curves were shifted toward the right by losartan but not by PD 123319 in both the vena cava and femoral vein. Moreover, it was observed that both 10(-5) M indomethacin and 10(-4) M L-NAME improve the angiotensin II responses in the vena cava and femoral vein. In conclusion, in the rat vena cava and femoral vein, angiotensin II stimulates AT(1) but not AT(2) to induce venoconstriction, which is blunted by vasodilator prostanoids and NO. (C) 2010 Elsevier Inc. All rights reserved.

Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)[05/51550-4]

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Identificador

PEPTIDES, v.32, n.1, p.112-117, 2011

0196-9781

http://producao.usp.br/handle/BDPI/27835

10.1016/j.peptides.2010.10.010

http://dx.doi.org/10.1016/j.peptides.2010.10.010

Idioma(s)

eng

Publicador

ELSEVIER SCIENCE INC

Relação

Peptides

Direitos

restrictedAccess

Copyright ELSEVIER SCIENCE INC

Palavras-Chave #Angiotensin II #Femoral vein #Nitric Oxide #Prostanoids #Receptor #Vena cava #END-DIASTOLIC VOLUME #ISOLATED PORTAL-VEIN #FLUID SHEAR-STRESS #ENDOTHELIAL-CELLS #SMOOTH-MUSCLE #ACTIVE VENOCONSTRICTION #SPLANCHNIC CIRCULATION #EXERCISE INCREASES #HYPERTENSIVE-RATS #CONSCIOUS RATS #Biochemistry & Molecular Biology #Pharmacology & Pharmacy
Tipo

article

original article

publishedVersion