EXPRESSION OF COCAINE- AND AMPHETAMINE-REGULATED TRANSCRIPT IN THE RAT FOREBRAIN DURING POSTNATAL DEVELOPMENT
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
20/10/2012
20/10/2012
2011
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Resumo |
Cocaine- and amphetamine-regulated transcript (CART) is widespread in the rodent brain. CART has been implicated in many different functions including reward, feeding, stress responses, sensory processing, learning and memory formation. Recent studies have suggested that CART may also play a role in neural development. Therefore, in the present study we compared the distribution pattern and levels of CART mRNA expression in the forebrain of male and female rats at different stages of postnatal development: P06, P26 and P66. At 6 days of age (P06), male and female rats showed increased CART expression in the somatosensory and piriform cortices, indusium griseum, dentate gyrus, nucleus accumbens, and ventral premammillary nucleus. Interestingly, we found a striking expression of CART mRNA in the ventral posteromedial and ventral posterolateral thalamic nuclei. This thalamic expression was absent at P26 and P66. Contrastingly, at P06 CART mRNA expression was decreased in the arcuate nucleus. Comparing sexes, we found increased CART mRNA expression in the anteroventral periventricular nucleus of adult females. In other regions including the CA1, the lateral hypothalamic area and the dorsomedial nucleus of the hypothalamus, CART expression was not different comparing postnatal ages and sexes. Our findings indicate that CART gene expression is induced in a distinct temporal and spatial manner in forebrain sites of male and female rats. They also suggest that CART peptide participate in the development of neural pathways related to selective functions including sensory processing, reward and memory formation. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) FAPESP NIH[HD061539] U.S. National Institutes of Health (NIH) Regent`s Scholar Research and President`s Council Regent`s Scholar Research and President`s Council |
Identificador |
NEUROSCIENCE, v.195, p.201-214, 2011 0306-4522 http://producao.usp.br/handle/BDPI/27826 10.1016/j.neuroscience.2011.08.036 |
Idioma(s) |
eng |
Publicador |
PERGAMON-ELSEVIER SCIENCE LTD |
Relação |
Neuroscience |
Direitos |
restrictedAccess Copyright PERGAMON-ELSEVIER SCIENCE LTD |
Palavras-Chave | #cerebral cortex #somatosensory cortex #hippocampus #ventral premammillary nucleus #thalamus #VENTRAL PREMAMMILLARY NUCLEUS #ANTEROVENTRAL PERIVENTRICULAR NUCLEUS #MELANIN-CONCENTRATING HORMONE #CART PEPTIDE #NEUROTROPHIC FACTOR #MESSENGER-RNA #IMMUNOHISTOCHEMICAL LOCALIZATION #SYNAPTIC-INTERACTIONS #SOMATOSENSORY CORTEX #HIPPOCAMPAL-NEURONS #Neurosciences |
Tipo |
article original article publishedVersion |