Reduction of acethylcolinesterase activity in the brain of mdx mice
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
20/10/2012
20/10/2012
2011
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Resumo |
Lack of dystrophin in brain structures have been involved with impaired cognitive functions. Acethylcolinesterase (AChE) is implicated in many cognitive functions and probably plays important roles in neurodegenerative disorders. In the present study, we investigated AChE activity in the prefrontal cortex, hippocampus, striatum and cortex of mdx mice. To this aim, brain tissues from male dystrophic mdx and normal control mice were used. We observed that mdx mice display a reduction in AChE activity of 40-60% in all brain structures evaluated. In conclusion, dystrophin deficiency may be affecting AChE activity and contributing negatively, in part, to memory storage and restoring. (C) 2011 Elsevier B.V. All rights reserved. Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) CNPq FAPESC Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina (FAPESC) United Nations Educational, Scientific and Cultural Organization (UNESCO) UNESC |
Identificador |
NEUROMUSCULAR DISORDERS, v.21, n.5, p.359-362, 2011 0960-8966 http://producao.usp.br/handle/BDPI/27559 10.1016/j.nmd.2011.02.017 |
Idioma(s) |
eng |
Publicador |
PERGAMON-ELSEVIER SCIENCE LTD |
Relação |
Neuromuscular Disorders |
Direitos |
restrictedAccess Copyright PERGAMON-ELSEVIER SCIENCE LTD |
Palavras-Chave | #mdx #Brain #Acethylcolinesterase #DUCHENNE MUSCULAR-DYSTROPHY #ACETYLCHOLINESTERASE ACTIVITY #ALPHA-DYSTROGLYCAN #NITRIC-OXIDE #MUSCLE #MOUSE #DEFICIENT #DISEASE #COMPLEX #NERVE #Clinical Neurology #Neurosciences |
Tipo |
article original article publishedVersion |