MITOCHONDRIAL RESPIRATORY CHAIN AND CREATINE KINASE ACTIVITIES IN mdx MOUSE BRAIN
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
20/10/2012
20/10/2012
2010
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| Resumo |
In this study we investigated energy metabolism in the mdx mouse brain. To this end, prefrontal cortex, cerebellum, hippocampus, striatum, and cortex were analyzed. There was a decrease in Complex I but not in Complex 11 activity in all structures. There was an increase in Complex III activity in striatum and a decrease in Complex IV activity in prefrontal cortex and striatum. Mitochondrial creatine kinase activity was increased in hippocampus, prefrontal cortex, cortex, and striatum. Our results indicate that there is energy metabolism dysfunction in the mdx mouse brain. Muscle Nerve 41: 257-260, 2010 CNPq Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina (FAPESC) FAPESC Instituto Cerebro e Mente Instituto Cerebro e Mente United Nations Educational, Scientific and Cultural Organization (UNESCO) UNESC |
| Identificador |
MUSCLE & NERVE, v.41, n.2, p.257-260, 2010 0148-639X http://producao.usp.br/handle/BDPI/27518 10.1002/mus.21559 |
| Idioma(s) |
eng |
| Publicador |
JOHN WILEY & SONS INC |
| Relação |
Muscle & Nerve |
| Direitos |
restrictedAccess Copyright JOHN WILEY & SONS INC |
| Palavras-Chave | #mdx mouse #mitochondrial respiratory chain #creatine kinase #brain #DUCHENNE MUSCULAR-DYSTROPHY #OXIDATIVE-PHOSPHORYLATION #SYNAPTIC-TRANSMISSION #MUSCLE #MICE #LOCALIZATION #UTROPHIN #HYPOXIA #NEURONS #SYSTEM #Clinical Neurology #Neurosciences |
| Tipo |
article original article publishedVersion |
