Homocysteine Thiolactone Induces Cardiac Dysfunction: Role of Oxidative Stress
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
19/10/2012
19/10/2012
2010
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Resumo |
This study investigates the cardiac functioning in male Wistar rats after treatments with methionine and homocysteine thiolactone (HcyT). The rats were distributed into 3 groups and treated for 8 weeks. Group I was the control (CO) group, given water, group II was treated with methionine, and group III with HcyT (100 mg/kg). Morphometric and functional cardiac parameters were evaluated by echocardiography. Superoxide dismutase (SOD), catalase, and glutathione S-transferase activities, chemiluminescence, thiobarbituric acid reactive substances, and immunocontent were measured in the myocardium. Hyperhomocysteinemia was observed in rats submitted to the both treatments. The results showed diastolic function was compromised in HcyT group, seen by the increase of E/A (peak velocity of early (E) and late (A) diastolic filling) ratio, decrease in deceleration time of E wave and left ventricular isovolumic relaxation time. Myocardial performance index was increased in HcyT group and was found associated with increased SOD immunocontent. HcyT group demonstrated an increase in SOD, catalase, and glutatione S-transferase activity, and chemiluminescence and thiobarbituric acid reactive substances. Overall, these results indicated that HcyT induces a cardiac dysfunction and could be associated with oxidative stress increase in the myocardium. |
Identificador |
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, v.55, n.2, p.198-202, 2010 0160-2446 http://producao.usp.br/handle/BDPI/27218 10.1097/FJC.0b013e3181ce5c28 |
Idioma(s) |
eng |
Publicador |
LIPPINCOTT WILLIAMS & WILKINS |
Relação |
Journal of Cardiovascular Pharmacology |
Direitos |
restrictedAccess Copyright LIPPINCOTT WILLIAMS & WILKINS |
Palavras-Chave | #hyperhomocysteinemia #methionine #cardiac function #antioxidant enzymes #oxidative stress #PATHOLOGICAL VENTRICULAR HYPERTROPHY #PLASMA HOMOCYSTEINE #HYPERHOMOCYSTEINEMIA #RATS #DISEASE #METABOLISM #HEART #ATHEROSCLEROSIS #ACTIVATION #MODEL #Cardiac & Cardiovascular Systems #Pharmacology & Pharmacy |
Tipo |
article original article publishedVersion |