Reactive nitrogen intermediate susceptibility of Mycobacterium tuberculosis genotypes in an urban setting
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
19/10/2012
19/10/2012
2009
|
| Resumo |
BACKGROUND: Mycobacterium tuberculosis genotypes resistant to reactive nitrogen intermediates (RNI) predominate in certain urban communities, suggesting that this phenotype influences disease transmission. OBJECTIVE: To compare different M. tuberculosis genotypes for resistance to RNI generated in vitro. DESIGN: We genotyped 420 M. tuberculosis isolates from a neighborhood in Sao Paulo, Brazil, and analyzed them for susceptibility to RNI generated in acidified sodium nitrite (ASN) solution. RESULTS: Seventy-one (43%) of 167 recent-infection strains and 68 (43%) of 158 endogenous infection strains showed moderate- to high-level ASN resistance. CONCLUSION: ASN resistance of M. tuberculosis is not necessarily a determining factor for enhanced transmission. Conselho Nacional cle Desenvolvimento Cientifico e Tecnologico (CNPq) NIH Fogarty International Center[TW006563] |
| Identificador |
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, v.13, n.5, p.665-668, 2009 1027-3719 |
| Idioma(s) |
eng |
| Publicador |
INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) |
| Relação |
International Journal of Tuberculosis and Lung Disease |
| Direitos |
restrictedAccess Copyright INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) |
| Palavras-Chave | #Mycobacterium tuberculosis #nitric oxide #RNI #RFLP #ASN #STRAIN #TRANSMISSION #COMMUNITY #Infectious Diseases #Respiratory System |
| Tipo |
article original article publishedVersion |
