Caffeic and chlorogenic acids in Ilex paraguariensis extracts are the main inhibitors of AGE generation by methylglyoxal in model proteins


Autoria(s): GUGLIUCCI, A.; BASTOS, Deborah H. Markowicz; SCHULZE, John; SOUZA, Marina F. Ferreira
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2009

Resumo

The present study concentrates on the evaluation of the anti-glycation effect of some bioactive substances present in yerba mate (Ilex paraguariensis): 5-caffeoylquinic acid, caffeic acid and a sapogenin (oleanolic acid). Bovine serum albumin and histones were incubated in the presence of methylglyoxal with or without the addition of 5-caffeoylquinic acid, caffeic acid and oleanolic acid. After the incubation period, advanced glycation end product (AGE) fluorescence spectra were performed and protein structural changes were evaluated by Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis. Chlorogenic acid, caffeic acid are the main substances responsible for the anti-glycation effect of mate tea. (C) 2009 Elsevier B.V. All rights reserved.

FAPESP (Brazil)

Touro University

Identificador

FITOTERAPIA, v.80, n.6, p.339-344, 2009

0367-326X

http://producao.usp.br/handle/BDPI/26710

10.1016/j.fitote.2009.04.007

http://dx.doi.org/10.1016/j.fitote.2009.04.007

Idioma(s)

eng

Publicador

ELSEVIER SCIENCE BV

Relação

Fitoterapia

Direitos

restrictedAccess

Copyright ELSEVIER SCIENCE BV

Palavras-Chave #Phenolic acids #Saponin #Glycation #Nutraceutical #Ilex paraguariensis #URSOLIC ACID #RAT HEPATOCYTES #LIVER-DAMAGE #GREEN TEA #IN-VITRO #GLYCOSYLATION #GLYCOXIDATION #ANTIOXIDANT #SAPONINS #CELLS #Chemistry, Medicinal #Pharmacology & Pharmacy
Tipo

article

original article

publishedVersion