Caffeic and chlorogenic acids in Ilex paraguariensis extracts are the main inhibitors of AGE generation by methylglyoxal in model proteins
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
19/10/2012
19/10/2012
2009
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Resumo |
The present study concentrates on the evaluation of the anti-glycation effect of some bioactive substances present in yerba mate (Ilex paraguariensis): 5-caffeoylquinic acid, caffeic acid and a sapogenin (oleanolic acid). Bovine serum albumin and histones were incubated in the presence of methylglyoxal with or without the addition of 5-caffeoylquinic acid, caffeic acid and oleanolic acid. After the incubation period, advanced glycation end product (AGE) fluorescence spectra were performed and protein structural changes were evaluated by Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis. Chlorogenic acid, caffeic acid are the main substances responsible for the anti-glycation effect of mate tea. (C) 2009 Elsevier B.V. All rights reserved. FAPESP (Brazil) Touro University |
Identificador |
FITOTERAPIA, v.80, n.6, p.339-344, 2009 0367-326X http://producao.usp.br/handle/BDPI/26710 10.1016/j.fitote.2009.04.007 |
Idioma(s) |
eng |
Publicador |
ELSEVIER SCIENCE BV |
Relação |
Fitoterapia |
Direitos |
restrictedAccess Copyright ELSEVIER SCIENCE BV |
Palavras-Chave | #Phenolic acids #Saponin #Glycation #Nutraceutical #Ilex paraguariensis #URSOLIC ACID #RAT HEPATOCYTES #LIVER-DAMAGE #GREEN TEA #IN-VITRO #GLYCOSYLATION #GLYCOXIDATION #ANTIOXIDANT #SAPONINS #CELLS #Chemistry, Medicinal #Pharmacology & Pharmacy |
Tipo |
article original article publishedVersion |