Immunohistochemical Analysis of Proliferating Cell Nuclear Antigen (PCNA) in Dental Follicles of Impacted Third Molars


Autoria(s): OLIVEIRA, David Moraes de; SILVEIRA, Marcia Maria Ferreira da; ANDRADE, Emanuel Savio de Souza; SOBRAL, Ana Paula Veras; MARTINS-FILHO, Paulo Ricardo Saquete; SANTOS, Thiago de Santana; OLIVEIRA, Patricia Leimig Amorim de
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2011

Resumo

This study investigated the immunodetection of PCNA in epithelial components of dental follicles associated with impacted third molars without radiographical and morphological signs of pathosis. A total of 105 specimens of dental follicles associated with impacted third molars with incomplete rhizogenesis (between Nolla`s stage 6 and 9) were surgically removed from 56 patients. Epithelial cell proliferating was determined by using immunohistochemical labeling. Statistical analysis was performed using the Fisher exact test. Of the 105 dental follicles collected, 6 were PCNA-positive (approximate to 6%). The specimens with squamous metaplasia and epithelial hyperplasia had higher rates of positivity for PCNA, as well as those with proliferative remnants of odontogenic epithelium. In conclusion, this study shows that dental follicles at this stage of development have low proliferative potential, but suggests that squamous metaplasia, hyperplasia of the epithelial lining and presence of proliferative odontogenic epithelial rests in the connective tissue may be early signs of developing lesions of odontogenic origin.

CNPq

CAPES

Identificador

INTERNATIONAL JOURNAL OF MORPHOLOGY, v.29, n.2, p.526-531, 2011

0717-9502

http://producao.usp.br/handle/BDPI/26504

http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000293661000037&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord

Idioma(s)

eng

Publicador

SOC CHILENA ANATOMIA

Relação

International Journal of Morphology

Direitos

openAccess

Copyright SOC CHILENA ANATOMIA

Palavras-Chave #Immunohistochemistry #Dental Sac #Third Molar #CYSTS #AMELOBLASTOMAS #3RD-MOLARS #Anatomy & Morphology
Tipo

article

original article

publishedVersion