GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk.

Autoria(s): Hughan, Sascha C; Hughes, Craig E; McCarty, Owen J T; Schweighoffer, Edina; Soultanova, Izoumroud; Ware, Jerry; Tybulewicz, Victor L J; Watson, Steve P
Data(s)

01/02/2007
Resumo

We show that Syk is critical for lamellipodia formation on a range of immobilized proteins but that this can be overcome by addition of thrombin. Further, we reveal a novel role for GPVI in supporting thrombin-induced activation, independent of Syk and Src kinases.
Formato

text
Identificador

http://centaur.reading.ac.uk/44584/1/Hughan%20ATVB%202007.pdf

Hughan, S. C., Hughes, C. E. <http://centaur.reading.ac.uk/view/creators/90006851.html>, McCarty, O. J. T., Schweighoffer, E., Soultanova, I., Ware, J., Tybulewicz, V. L. J. and Watson, S. P. (2007) GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk. Arteriosclerosis, thrombosis, and vascular biology, 27 (2). pp. 422-9. ISSN 1524-4636
Idioma(s)

en
Relação

http://centaur.reading.ac.uk/44584/

creatorInternal Hughes, Craig E
Tipo

Article

PeerReviewed
Acesso ao item digital