Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2.
| Data(s) |
01/12/2008
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|---|---|
| Resumo |
The results demonstrate that Gads plays a key role in linking the adapter LAT to SLP-76 in response to weak activation of GPVI and CLEC-2 whereas LAT is required for full activation over a wider range of agonist concentrations. These results reveal the presence of a Gads-independent pathway of platelet activation downstream of LAT. |
| Formato |
text |
| Identificador |
http://centaur.reading.ac.uk/44581/1/Hughes%20et%20al%20JTH%202008.pdf Hughes, C. E. <http://centaur.reading.ac.uk/view/creators/90006851.html>, Auger, J. M., McGlade, J., Eble, J. A., Pearce, A. C. and Watson, S. P. (2008) Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2. Journal of thrombosis and haemostasis : JTH, 6 (12). pp. 2152-9. ISSN 1538-7836 |
| Idioma(s) |
en |
| Relação |
http://centaur.reading.ac.uk/44581/ creatorInternal Hughes, C E |
| Tipo |
Article PeerReviewed |
