The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets.
| Data(s) |
01/07/2009
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| Resumo |
The inhibitory effect of R406 provides direct evidence of a role for Syk in GPVI, CLEC-2 and integrin alphaIIbbeta3 signaling in human platelets. Further, the results demonstrate a critical role for Syk in mediating tyrosine phosphorylation of CLEC-2, suggesting a novel model in which both Src and Syk kinases regulate tyrosine phosphorylation of the C-type lectin receptor leading to platelet activation. |
| Formato |
text |
| Identificador |
http://centaur.reading.ac.uk/44578/1/Spalton%20et%20al%20JTH%202009.pdf Spalton, J. C., Mori, J., Pollitt, A. Y. <http://centaur.reading.ac.uk/view/creators/90006835.html>, Hughes, C. E. <http://centaur.reading.ac.uk/view/creators/90006851.html>, Eble, J. A. and Watson, S. P. (2009) The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets. Journal of thrombosis and haemostasis : JTH, 7 (7). pp. 1192-9. ISSN 1538-7836 |
| Idioma(s) |
en |
| Relação |
http://centaur.reading.ac.uk/44578/ creatorInternal Pollitt, A Y creatorInternal Hughes, C E |
| Tipo |
Article PeerReviewed |
