A comparison of methods for treatment selection in seamless phase II/III clinical trials incorporating information on short-term endpoints


Autoria(s): Kunz, Cornelia Ursula; Friede, Tim; Parsons, Nicholas; Todd, Susan; Stallard, Nigel
Data(s)

01/01/2015

Resumo

In an adaptive seamless phase II/III clinical trial interim analysis, data are used for treatment selection, enabling resources to be focused on comparison of more effective treatment(s) with a control. In this paper, we compare two methods recently proposed to enable use of short-term endpoint data for decision-making at the interim analysis. The comparison focuses on the power and the probability of correctly identifying the most promising treatment. We show that the choice of method depends on how well short-term data predict the best treatment, which may be measured by the correlation between treatment effects on short- and long-term endpoints.

Formato

text

Identificador

http://centaur.reading.ac.uk/39111/1/10543406%252E2013%252E840646.pdf

Kunz, C. U., Friede, T., Parsons, N., Todd, S. <http://centaur.reading.ac.uk/view/creators/90000461.html> and Stallard, N. (2015) A comparison of methods for treatment selection in seamless phase II/III clinical trials incorporating information on short-term endpoints. Journal of Biopharmaceutical Statistics, 25 (1). pp. 170-189. ISSN 1054-3406 doi: 10.1080/10543406.2013.840646 <http://dx.doi.org/10.1080/10543406.2013.840646>

Idioma(s)

en

Publicador

Taylor & Francis

Relação

http://centaur.reading.ac.uk/39111/

creatorInternal Todd, Susan

10.1080/10543406.2013.840646

Direitos

cc_by

Tipo

Article

PeerReviewed