Zinc mediated azide-alkyne ligation to 1,5- and 1,4,5-substituted 1,2,3-triazoles
| Data(s) |
03/09/2013
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|---|---|
| Resumo |
A mild method for regioselective formation of 1,5-substituted 1,2,3-triazoles is described. The zinc-mediated reaction works at room temperature and is successful across a wide range of azido/alkynyl substrates. Additionally, the triazole 4-position can be further functionalized through the intermediate aryl-zinc to accommodate a diverse three-component coupling strategy. |
| Formato |
text |
| Identificador |
http://centaur.reading.ac.uk/37106/1/CS%20Jul%2014%20-%20ol402225d.pdf Smith, C. D. <http://centaur.reading.ac.uk/view/creators/90006042.html> and Greaney, M. F. (2013) Zinc mediated azide-alkyne ligation to 1,5- and 1,4,5-substituted 1,2,3-triazoles. Organic Letters, 15 (18). pp. 4826-4829. ISSN 1523-7060 doi: 10.1021/ol402225d <http://dx.doi.org/10.1021/ol402225d> |
| Idioma(s) |
en |
| Publicador |
The American Chemical Society |
| Relação |
http://centaur.reading.ac.uk/37106/ creatorInternal Smith, Christopher D. 10.1021/ol402225d |
| Direitos |
cc_by_4 |
| Tipo |
Article PeerReviewed |
