Local orientational disorder in peptide fibrils probed by a combination of residue-specific 13C-18O labelling, polarised infrared spectroscopy and molecular combing
| Data(s) |
01/08/2012
|
|---|---|
| Resumo |
A novel combination of site-specific isotope labelling, polarised infrared spectroscopy and molecular combing reveal local orientational ordering in the fibril-forming peptide YTIAALLSPYSGGRADS. Use of 13C-18O labelled alanine residues demonstrates that the Nterminal end of the peptide is incorporated into the cross-beta structure, while the C-terminal end shows orientational disorder |
| Formato |
text |
| Identificador |
http://centaur.reading.ac.uk/30241/1/RodriguezChemComm12_CENTAUR%20-AMS.pdf Rodríguez-Pérez, J. C., Hamley, I. W. <http://centaur.reading.ac.uk/view/creators/90000472.html>, Gras, S. L. and Squires, A. M. <http://centaur.reading.ac.uk/view/creators/90000507.html> (2012) Local orientational disorder in peptide fibrils probed by a combination of residue-specific 13C-18O labelling, polarised infrared spectroscopy and molecular combing. Chemical Communications, 48. pp. 11835-11837. ISSN 1359-7345 doi: 10.1039/C2CC35586H <http://dx.doi.org/10.1039/C2CC35586H> |
| Idioma(s) |
en |
| Publicador |
The Royal Society of Chemistry |
| Relação |
http://centaur.reading.ac.uk/30241/ creatorInternal Hamley, Ian W. creatorInternal Squires, Adam M. 10.1039/C2CC35586H |
| Tipo |
Article PeerReviewed |
