Prefrontal control of familiarity and recollection in working memory


Autoria(s): Feredoes, Eva; Postle, Bradley R
Data(s)

01/02/2010

Resumo

Left inferior frontal gyrus (IFG) is a critical neural substrate for the resolution of proactive interference (PI) in working memory. We hypothesized that left IFG achieves this by controlling the influence of familiarity- versus recollection-based information about memory probes. Consistent with this idea, we observed evidence for an early (200 msec)-peaking signal corresponding to memory probe familiarity and a late (500 msec)-resolving signal corresponding to full accrual of trial-related contextual ("recollection-based") information. Next, we applied brief trains of repetitive transcranial magnetic stimulation (rTMS) time locked to these mnemonic signals, to left IFG and to a control region. Only early rTMS of left IFG produced a modulation of the false alarm rate for high-PI probes. Additionally, the magnitude of this effect was predicted by individual differences in susceptibility to PI. These results suggest that left IFG-based control may bias the influence of familiarity- and recollection-based signals on recognition decisions.

Formato

text

Identificador

http://centaur.reading.ac.uk/28379/1/Feredoes_Journal%20of%20cognitive%20neuroscience2010.pdf

Feredoes, E. <http://centaur.reading.ac.uk/view/creators/90004594.html> and Postle, B. R. (2010) Prefrontal control of familiarity and recollection in working memory. Journal of Cognitive Neuroscience, 22 (2). pp. 323-30. ISSN 0898-929X doi: 10.1162/jocn.2009.21252 <http://dx.doi.org/10.1162/jocn.2009.21252>

Idioma(s)

en

Publicador

M I T Press

Relação

http://centaur.reading.ac.uk/28379/

creatorInternal Feredoes, Eva

10.1162/jocn.2009.21252

Tipo

Article

PeerReviewed