Association between dietary phyto-oestrogens and bone density in men and postmenopausal women


Autoria(s): Kuhnle, Gunter G. C.; Ward, Heather A.; Vogiatzoglou, Anna; Luben, Robert N.; Mulligan, Angela; Wareham, Nicholas J.; Forouhi, N. G.; Khaw, Kay-Tee
Data(s)

14/10/2011

Resumo

Phyto-oestrogens have been associated with a decreased risk for osteoporosis, but results from intervention and observational studies in Western countries have been inconsistent. In the present study, we investigated the association between habitual phyto-oestrogen intake and broadband ultrasound attenuation (BUA) of the calcanaeum as a marker of bone density. We collected 7 d records of diet, medical history and demographic and anthropometric data from participants (aged 45–75 years) in the European Prospective Investigation into Cancer-Norfolk study. Phyto-oestrogen (biochanin A, daidzein, formononetin; genistein, glycitein; matairesinol; secoisolariciresinol; enterolactone; equol) intake was determined using a newly developed food composition database. Bone density was assessed using BUA of the calcanaeum. Associations between bone density and phyto-oestrogen intake were investigated in 2580 postmenopausal women who were not on hormone replacement therapy and 4973 men. Median intake of total phyto-oestrogens was 876 (interquartile range 412) μg/d in postmenopausal women and 1212 (interquartile range 604) μg/d in men. The non-soya isoflavones formononetin and biochanin A were marginally significant or significantly associated with BUA in postmenopausal women (β = 1·2; P < 0·1) and men (β = 1·2; P < 0·05), respectively; enterolignans and equol were positively associated with bone density in postmenopausal women, but this association became non-significant when dietary Ca was added to the model. In the lowest quintile of Ca intake, soya isoflavones were positively associated with bone density in postmenopausal women (β = 1·4; P < 0·1). The present results therefore suggest that non-soya isoflavones are associated with bone density independent of Ca, whereas the association with soya or soya isoflavones is affected by dietary Ca.

Formato

text

Identificador

http://centaur.reading.ac.uk/20335/1/pe_bone_density.pdf

Kuhnle, G. G. C. <http://centaur.reading.ac.uk/view/creators/90002679.html>, Ward, H. A., Vogiatzoglou, A. <http://centaur.reading.ac.uk/view/creators/90003838.html>, Luben, R. N., Mulligan, A., Wareham, N. J., Forouhi, N. G. and Khaw, K.-T. (2011) Association between dietary phyto-oestrogens and bone density in men and postmenopausal women. British Journal of Nutrition, 106 (7). pp. 1063-1069. ISSN 0007-1145 doi: 10.1017/S0007114511001309 <http://dx.doi.org/10.1017/S0007114511001309>

Idioma(s)

en

Publicador

Cambridge University Press

Relação

http://centaur.reading.ac.uk/20335/

creatorInternal Kuhnle, Gunter G. C.

creatorInternal Vogiatzoglou, Anna

10.1017/S0007114511001309

Tipo

Article

PeerReviewed