Eficacia diagnostica del ácido láctico en liquido cefalorraquídeo en meningitis postclipaje de aneurisma cerebral y hemorragia subaracnoidea
| Contribuinte(s) |
Villabona Luna, Rafael Beltran, Jhonny Becerra, Antonio |
|---|---|
| Data(s) |
17/07/2012
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| Resumo |
La concentración de ácido láctico en LCR en pacientes con sospecha de meningitis postquirúrgica luego de clipaje de aneurisma cerebral y hemorragia subaracnoidea espontánea se midió prospectivamente por un período de tres años. Se analizaron un total de 32 muestras de líquido cefalorraquídeo, se midió la concentración de ácido láctico y se comparó con el cultivo de LCR. Los cultivos fueron positivos en cinco pacientes, con una prevalencia de infección del 15%. Se utilizó un valor umbral de ácido láctico de 4 mmol/L. y se encontró una sensibilidad del 80%, especificidad del 52%, VPP del 23%, VPN del 93%, y likelihood ratio (LHR) positivo de 1,66 con una probabilidad post test de 15% de la concentración del ácido láctico en el diagnóstico de meningitis postquirúrgica en pacientes con hemorragia subaracnoidea aneurismática. La concentración de ácido láctico en LCR tiene un desempeño limitado en el diagnóstico de meningitis postquirúrgica en pacientes con hemorragia subaracnoidea aneurismática. The lactic acid concentration in cerebrospinal fluid (CSF) was measured in patients with suspected meningitis after aneurysmal clipaje for spontaneous subarachnoid hemorraghe. It was measured in a prospective way during a three years period time. In total were analyzed 32 samples of CSF, the lactic acid concentration was compared against culture of CSF. The CSF culture was positive in 5 patients, with a meningitis prevalence of 15%. We use a cut-off value of 4 mmol/L for lactic acid and we find a sensitivity of 80%, specificity of 52%, VPP of 23%, VPN of 93% and a positive LHR of 1.66 with a posttest probability of 15% for the lactic acid concentration in CSF for the diagnosis of meningitis in patients with aneurysmal clipaje and subarachnoid hemorrhage. The acid lactic concentration in CSF has a limited diagnostic efficacy in patients with subarachnoid hemorrhage and suspected postquirurgical meningitis. |
| Formato |
application/pdf |
| Identificador | |
| Idioma(s) |
spa |
| Publicador |
Facultad de Medicina |
| Direitos |
info:eu-repo/semantics/openAccess |
| Fonte |
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| Palavras-Chave | #ACIDO LACTICO - INVESTIGACIONES #MENINGITIS - INVESTIGACIONES #ENFERMEDADES DEL SISTEMA NERVIOSO CENTRAL - INVESTIGACIONES #cerebrospinal fluid #lactic acid #meningitis #subarachnoid hemorrhage |
| Tipo |
info:eu-repo/semantics/bachelorThesis info:eu-repo/semantics/acceptedVersion |
