Comparación de dos esquemas de preparación intestinal en niños llevados a colonoscopia: experimento clínico multicentrico

Objetivo: Comparar eficacia de PEG 3350 sin electrolitos y fosfato de sodio oral en preparación intestinal de niños previo a colonoscopia. Materiales y métodos: participaron 64 pacientes entre dos y dieciocho años, de ambos géneros, con indicación clínica de colonoscopia que acudieron a tres hospitales de Bogotá y asignados aleatoriamente a uno de dos brazos de intervención. Un grupo expuesto número 1 recibió PEG oral 2.5gr/kg/día por 2 días, un grupo control número 2 recibió Travad 133 ml/m2sc/día por 2 días, ambos grupos recibieron dieta líquida los días de preparación. Se evaluaron efectos adversos clínicos (cefalea, dolor abdominal, náuseas, vómito), adherencia y efectividad de cada uno de los manejos; se diligenció formulario en papel para cada participante, donde se interrogó efectos secundarios, días de preparación, cumplimiento de dieta e ingesta del medicamento y calidad de preparación. Resultados: 36 pacientes recibieron PEG y 28 fosfato de sodio, con edad media de 8.4 años y desviación estándar de 4.1. El 64.1% del género femenino. El 5.6% de pacientes con PEG no siguió las recomendaciones de dieta y un 10.7% del grupo de Travad. Un 61% del grupo de PEG y un 43% del grupo de Travad no tuvieron efectos adversos sin diferencias significativas (X²=0,14 p=0,073). La evaluación de calidad de la preparación entre los dos grupos no encontró diferencia significativa en su distribución, utilizando la prueba de X²=0,551 y una p=0,907. Conclusión: no hubo diferencias significativas entre los dos grupos. La adherencia fue en general buena y no hubo efectos adversos significativos.

Baxter laboratorio

Objective: To compare the efficiency of the Electrolyte-Free PEG-3350 versus Sodium Phosphate taken orally as a bowel cleanse for colonoscopy preparation in children. Study design: In this study, there were 64 patients consisting of both genders between 2-18 years old. The patients, who were admitted to three local hospitals, had clinical indication for colonoscopy. The patients were randomly divided into 2 groups. An exposed group assigned as group 1, was given PEG-3350 at a dose of 2.5gr/kg/day by mouth for 2 days prior to colonoscopy. A control group, assigned as group 2, was given Travad (Sodium Phosphate) at a dose of 133 ml/bsm2/day for 2 days. Both groups followed a liquid diet during the preparation days. Adverse effects (headache, abdominal pain, nausea, vomiting), compliance and effectiveness of each method were evaluated. Each participant was given a questionnaire regarding secondary effects, timing of preparation, diet, use and experience of the preparation. Parameters: Mean age 8.4yrs and standard deviation 4.1yrs. 64% of the patients were female, hence 36% of the patients were male. Group 1 (36 patients received PEG) and Group 2 (28 received Sodium Phosphate). Results: 5.6% of the patients who received PEG and 10.7% of the patients who received Sodium Phosphate did not follow the recommendations of diet. 61% of the group that received PEG and 43% of the group that received Sodium Phosphate did not experience any significant differentiating adverse effects (X²=0,14 p=0,073). Finally, the evaluation of the quality of the preparation between the two groups did not find significant differences in its distribution utilizing X²=0,551 and p=0,907.Conclusion: There were no significant differences between the two groups (PEG and Sodium Phosphate). The compliance was good and there were not significant adverse effects. Key words: “preparation”, “bowel”, “children”.