The Use of Ipso-dihydrodiols Enzymatically Derived from Benzoic Acid in Enantioselective Synthesis. Appoaches to Total Synthesis of Vinca Alkaloids
Contribuinte(s) |
Department of Chemistry |
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Data(s) |
18/07/2014
18/07/2014
18/07/2014
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Resumo |
The present studies describe our recent progress in target oriented synthesis of complex organic molecules from aromatic precursors. The latest synthetic approaches toward vinca alkaloids are described and include the construction of model substrates for the investigation into Diels-Alder, radical cascade, and tandem Michael addition reactions as possible routes to the family of alkaloids. Also described are the chemoenzymatic syntheses of the natural product (-)-idesolide and unnatural polyhydroxylated pyrrolidines generated from the biotransformation of benzoic acid with Ralstonia eutropha B9. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Brock University |
Palavras-Chave | #alkaloid synthesis chemoenzymatic organic chemistry |
Tipo |
Electronic Thesis or Dissertation |