The Use of Ipso-dihydrodiols Enzymatically Derived from Benzoic Acid in Enantioselective Synthesis. Appoaches to Total Synthesis of Vinca Alkaloids


Autoria(s): Adams, David
Contribuinte(s)

Department of Chemistry

Data(s)

18/07/2014

18/07/2014

18/07/2014

Resumo

The present studies describe our recent progress in target oriented synthesis of complex organic molecules from aromatic precursors. The latest synthetic approaches toward vinca alkaloids are described and include the construction of model substrates for the investigation into Diels-Alder, radical cascade, and tandem Michael addition reactions as possible routes to the family of alkaloids. Also described are the chemoenzymatic syntheses of the natural product (-)-idesolide and unnatural polyhydroxylated pyrrolidines generated from the biotransformation of benzoic acid with Ralstonia eutropha B9.

Identificador

http://hdl.handle.net/10464/5510

Idioma(s)

eng

Publicador

Brock University

Palavras-Chave #alkaloid synthesis chemoenzymatic organic chemistry
Tipo

Electronic Thesis or Dissertation