Chemoenzymatic Synthesis of ent-Neopinone
| Contribuinte(s) |
Department of Chemistry |
|---|---|
| Data(s) |
11/04/2013
11/04/2013
11/04/2013
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| Resumo |
The present thesis describes the chemoenzymatic synthesis of ent-neopinone. The total synthesis of neopinone was accomplished in 14 steps from B-bromoethylbenzene. The synthesis began with a microbial oxidation of bromobenzene by Escherichia coli JM109(pDTG601) and features a Heck reaction, aldol condensation and a 1,6-conjugate addition. |
| Identificador | |
| Palavras-Chave | #Neopinone #Chemoenzymatic synthesis |
