Multifactorial control of water and saline intake: role of a2-adrenoceptors


Autoria(s): Associação Brasileira de Divulgação Científica
Data(s)

01/04/1997

Resumo

Water and saline intake is controlled by several mechanisms activated during dehydration. Some mechanisms, such as the production of angiotensin II and unloading of cardiovascular receptors, activate both behaviors, while others, such as the increase in blood osmolality or sodium concentration, activate water, but inhibit saline intake. Aldosterone probably activates only saline intake. Clonidine, an <FONT FACE="Symbol">a</font>2-adrenergic agonist, inhibits water and saline intake induced by these mechanisms. One model to describe the interactions between these multiple mechanisms is a wire-block diagram, where the brain circuit that controls each intake is represented by a summing point of its respective inhibiting and activating factors. The <FONT FACE="Symbol">a</font>2-adrenoceptors constitute an inhibitory factor common to both summing points

Formato

text/html

Identificador

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000400011

Idioma(s)

en

Publicador

Associação Brasileira de Divulgação Científica

Fonte

Brazilian Journal of Medical and Biological Research v.30 n.4 1997

Palavras-Chave #sodium intake #water intake #clonidine #noradrenaline #dehydration #<FONT FACE=Symbol> a</font>2-adrenergic agonist
Tipo

journal article