Comparative study of the different degrees of risk of gastrointestinal stromal tumor


Autoria(s): Oliveira,Rodrigo Panno Basilio de; Portari Filho,Pedro Eder; Iglesias,Antonio Carlos; Oliveira,Carlos Alberto Basilio de; Pannain,Vera Lucia Nunes
Data(s)

01/02/2015

Resumo

OBJECTIVE: To evaluate the applicability of the main categories of risk and morphological factors in the prognosis of gastrointestinal stromal tumors. METHODS: we retrospectively studied fifty-four cases of GIST, assessing the main prognostic factors of this neoplasis: risk levels, topography, size, mitotic index, necrosis, histological subtype and immunophenotype. We also verified their association and the reduction of overall survival. RESULTS: Univariate analysis showed that tumors with mitoses number greater than 5 per 50CGA (high-power fields), the presence of necrosis and a high risk for both the systems proposed by Fletcher and Miettinen had a significant association with reduced survival (p = 0.00001, 0.0056, 0.03 and 0.009, respectively). The remaining analyzed factors (size, histological subtype, topography and immunophenotype) had no such association. Multivariate analysis (Jacard index) showed that the Miettinen degree of risk was the one that best correlated with prognosis. CONCLUSION: the risk criteria of Fletcher and Miettinen are important in assessing the prognosis of patients with gastrointestinal stromal tumors, especially the latter, which adds to the mitotic index and the presence of tumor necrosis.

Formato

text/html

Identificador

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912015000200032

Idioma(s)

en

Publicador

Colégio Brasileiro de Cirurgiões

Fonte

Revista do Colégio Brasileiro de Cirurgiões v.42 n.1 2015

Palavras-Chave #Gastrointestinal Stromal Tumors #Risk Factors #Digestive System Neoplasms #Prognosis #Mitotic Index
Tipo

journal article