Proteases virais: importantes alvos terapêuticos de compostos peptideomiméticos

Proteases catalyze the hydrolysis of peptide bonds of proteins and peptides to produce smaller peptides and free amino acids. These enzymes are involved in physiologic processes such as blood coagulation and cellular death, and are related to life cycle of several viruses, such as hepatitis C, dengue, and AIDS. These features make most of proteases very important therapeutic targets for new pharmaceutical compounds. The development of peptidemimetics with improved pharmacokinetic properties is driving extensive research in the field of viral protease inhibitors. The present paper aims to highlight the design and synthesis of peptidemimetics that are able to inhibit viral proteases related to hepatitis C, dengue, and AIDS.