Influência de processos antagônicos no desenvolvimento de sistema de análises em fluxo para a determinação espectrofotométrica de propiltiouracil em medicamentos


Autoria(s): Santana,Rodolfo de Melo Magalhães; Korn,Mauro; Santos,Josué Carinhanha Caldas
Data(s)

01/01/2013

Resumo

A multi-commuted flow system was developed to determine propylthiouracil (PTU) based on the reaction of its thiol form with iminoquinone radical generated by the oxidation of N,N-dimethyl-p-phenylenediamine in an alkaline medium. PTU can be found in tautomeric forms and the tautomeric equilibrium was displaced to enhance the thiol form. However, the reaction product is unstable and its residence time in the flow path was carefully investigated. The proposed procedure showed good precision (< 1.5%) and a limit of detection (3s) of 0.11 mg L-1. High recoveries were obtained in the validation test. The procedure was employed for propylthiouracil determination in medications.

Formato

text/html

Identificador

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000100017

Idioma(s)

pt

Publicador

Sociedade Brasileira de Química

Fonte

Química Nova v.36 n.1 2013

Palavras-Chave #tautomeric equilibrium #antagonist processes #propylthiouracil
Tipo

journal article