Synthesis of quinoxaline 1,4-di-N-oxide derivatives on solid support using room temperature and microwave-assisted solvent-free procedures


Autoria(s): Gómez-Caro,Lilia C; Sánchez-Sánchez,Mario; Bocanegra-García,Virgilio; Rivera,Gildardo; Monge,Antonio
Data(s)

01/01/2011

Resumo

We describe the synthesis of 12 new ethyl and methyl quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives on solid supports with room temperature and microwave-assisted solvent-free procedures. Results show that solid supports have good catalytic activity in the formation of quinoxaline 1,4-di-N-oxide derivatives. We found that florisil and montmorillonite KSF and K10 could be used as new, easily available, inexpensive alternatives of catalysts. Additionally, room temperature and microwave-irradiation solvent-free synthesis was more efficient than a conventional procedure (Beirut reaction), reducing reaction time and increasing yield.

Formato

text/html

Identificador

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000700008

Idioma(s)

en

Publicador

Sociedade Brasileira de Química

Fonte

Química Nova v.34 n.7 2011

Palavras-Chave #quinoxaline #solid supports #solvent-free
Tipo

journal article