Development and validation of UV spectrophotometric method for determination of levofloxacin in pharmaceutical dosage forms


Autoria(s): Kassab,Nájla Mohamad; Amaral,Marcos Serrou do; Singh,Anil Kumar; Santoro,Maria Inês Rocha Miritello
Data(s)

01/01/2010

Resumo

The objective of this research was to develop and validate an alternative analytical method for quantitative determination of levofloxacin in tablets and injection preparations. The calibration curves were linear over a concentration range from 3.0 to 8.0 μg mL-1. The relative standard deviation was below 1.0% for both formulations and average recovery was 101.42 ± 0.45% and 100.34 ± 0.85% for tablets and injection formulations, respectively. The limit of detection and limit of quantitation were 0.08 and 0.25 μg mL-1, respectively. It was concluded that the developed method is suitable for the quality control of levofloxacin in pharmaceuticals formulations.

Formato

text/html

Identificador

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000400037

Idioma(s)

en

Publicador

Sociedade Brasileira de Química

Fonte

Química Nova v.33 n.4 2010

Palavras-Chave #fluoroquinolone #UV spectrophotometry #quality control
Tipo

journal article