Development and validation of UV spectrophotometric method for determination of levofloxacin in pharmaceutical dosage forms
Data(s) |
01/01/2010
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Resumo |
The objective of this research was to develop and validate an alternative analytical method for quantitative determination of levofloxacin in tablets and injection preparations. The calibration curves were linear over a concentration range from 3.0 to 8.0 μg mL-1. The relative standard deviation was below 1.0% for both formulations and average recovery was 101.42 ± 0.45% and 100.34 ± 0.85% for tablets and injection formulations, respectively. The limit of detection and limit of quantitation were 0.08 and 0.25 μg mL-1, respectively. It was concluded that the developed method is suitable for the quality control of levofloxacin in pharmaceuticals formulations. |
Formato |
text/html |
Identificador |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000400037 |
Idioma(s) |
en |
Publicador |
Sociedade Brasileira de Química |
Fonte |
Química Nova v.33 n.4 2010 |
Palavras-Chave | #fluoroquinolone #UV spectrophotometry #quality control |
Tipo |
journal article |