Caracterização do complexo de inclusão ropivacaína: beta-ciclodextrina


Autoria(s): Fraceto,Leonardo Fernandes; Gonçalves,Marcos Moisés; Moraes,Carolina Morales; Araújo,Daniele Ribeiro de; Zanella,Luciana; Paula,Eneida de; Pertinhez,Thelma de Aguiar
Data(s)

01/10/2007

Resumo

Characteriza of the inclusion complex ropivacaine: beta-cyclodextrin. Ropivacaine (RVC) is a widely used local anesthetic. The complexation of RVC with beta-cyclodextrin (beta-CD) is of great interest for the development of more efficient local anesthetic formulations. The present work focuses on the characterization of the RVC:beta-CD complex by nuclear magnetic resonance (NMR). The stoichiometry of the complex is 1:2 RVC:beta-CD. DOSY-NMR shows that the association constant is 55.5 M-1. Longitudinal relaxation time results show that RVC changes its mobility in the presence of beta-CD. This study is focused on the physicochemical characterization of inclusion complexes that are potentials options for pain treatment.

Formato

text/html

Identificador

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000500028

Idioma(s)

pt

Publicador

Sociedade Brasileira de Química

Fonte

Química Nova v.30 n.5 2007

Palavras-Chave #ropivacaine #cyclodextrin #NMR
Tipo

journal article