Atividades larvicida e anticolinesterásica de plantas do gênero Kalanchoe


Autoria(s): Trevisan,Maria Teresa Salles; Bezerra,Maria Zeneide Barbosa; Santiago,Gilvandete Maria Pinheiro; Feitosa,Chistiane Mendes; Verpoorte,Robert; Braz Filho,Raimundo
Data(s)

01/06/2006

Resumo

Acetylcholine esterase inhibitors are successfully used to treat the symptoms of Alzheimer's disease. Extracts of three Kalanchoe species (K. brasiliensis, K. pinnata and K. gastonis-bornieri) showed acetylcholine esterase inhibitory effects and a toxic effect on Aedes aegypti larvae. Here we describe the bioassay guided fractionation of extracts of the most active extracts (K. brasiliensis) which resulted in the isolation of an active mixture of three flavonoids: 8-methoxyquercetin, 3,7-di-O-rhamnopyranoside and 8-methoxykaempferol-3,7-di-O-rhamnopyranoside. On TLC these flavonoids showed an acetylcholine esterase inhibitory effect.

Formato

text/html

Identificador

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000300002

Idioma(s)

pt

Publicador

Sociedade Brasileira de Química

Fonte

Química Nova v.29 n.3 2006

Palavras-Chave #Kalanchoe species #flavonol glycosides #Alzheimer's disease
Tipo

journal article