Caracterização e estabilidade físico-química de sistemas poliméricos nanoparticulados para administração de fármacos


Autoria(s): Schaffazick,Scheila Rezende; Guterres,Sílvia Stanisçuaski; Freitas,Liane de Lucca; Pohlmann,Adriana Raffin
Data(s)

01/10/2003

Resumo

Polymeric nanoparticle systems such as nanocapsules and nanospheres present potential applications for the administration of therapeutic molecules. The physico-chemical characteristics of nanoparticle suspensions are important pre-requisites of the success of any dosage form development. The purpose of this review is to present the state of the art regarding the physico-chemical characterization of these drug carriers, in terms of the particle size distribution, the morphology, the polymer molecular weight, the surface charge, the drug content and the in vitro drug release profiles. Part of the review is devoted to the description of the techniques to improve the stability of colloidal systems.

Formato

text/html

Identificador

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422003000500017

Idioma(s)

pt

Publicador

Sociedade Brasileira de Química

Fonte

Química Nova v.26 n.5 2003

Palavras-Chave #nanoparticles #polymers #characterization
Tipo

journal article