Personalized approaches to active immunotherapy in cancer


Autoria(s): Ophir, Eran; Bobisse, Sara; Coukos, George; Harari, Alexandre; Kandalaft, Lana E.
Data(s)

01/01/2016

Resumo

Immunotherapy is emerging as a promising anti-cancer curative modality. However, in contrast to recent advances obtained employing checkpoint blockade agents and T cell therapies, clinical efficacy of therapeutic cancer vaccines is still limited. Most vaccination attempts in the clinic represent "off-the shelf" approaches since they target common "self" tumor antigens, shared among different patients. In contrast, personalized approaches of vaccination are tailor-made for each patient and in spite being laborious, hold great potential. Recent technical advancement enabled the first steps in the clinic of personalized vaccines that target patient-specific mutated neo-antigens. Such vaccines could induce enhanced tumor-specific immune response since neo-antigens are mutation-derived antigens that can be recognized by high affinity T cells, not limited by central tolerance. Alternatively, the use of personalized vaccines based on whole autologous tumor cells, overcome the need for the identification of specific tumor antigens. Whole autologous tumor cells could be administered alone, pulsed on dendritic cells as lysate, DNA, RNA or delivered to dendritic cells in-vivo through encapsulation in nanoparticle vehicles. Such vaccines may provide a source for the full repertoire of the patient-specific tumor antigens, including its private neo-antigens. Furthermore, combining next-generation personalized vaccination with other immunotherapy modalities might be the key for achieving significant therapeutic outcome.

Identificador

https://serval.unil.ch/notice/serval:BIB_01C8158A4FDC

info:pmid:26241169

pmid:26241169

doi:10.1016/j.bbcan.2015.07.004

isiid:000371359200008

Idioma(s)

eng

Fonte

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer1865172-82

Tipo

info:eu-repo/semantics/review

article

Palavras-Chave #Genetics; Cancer Research; Oncology