Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.

Autoria(s): Pattaro C.; Teumer A.; Gorski M.; Chu A.Y.; Li M.; Mijatovic V.; Garnaas M.; Tin A.; Sorice R.; Li Y.; Taliun D.; Olden M.; Foster M.; Yang Q.; Chen M.H.; Pers T.H.; Johnson A.D.; Ko Y.A.; Fuchsberger C.; Tayo B.; Nalls M.; Feitosa M.F.; Isaacs A.; Dehghan A.; d'Adamo P.; Adeyemo A.; Dieffenbach A.K.; Zonderman A.B.; Nolte I.M.; van der Most P.J.; Wright A.F.; Shuldiner A.R.; Morrison A.C.; Hofman A.; Smith A.V.; Dreisbach A.W.; Franke A.; Uitterlinden A.G.; Metspalu A.; Tonjes A.; Lupo A.; Robino A.; Johansson Å.; Demirkan A.; Kollerits B.; Freedman B.I.; Ponte B.; Oostra B.A.; Paulweber B.; Krämer B.K.; Mitchell B.D.; Buckley B.M.; Peralta C.A.; Hayward C.; Helmer C.; Rotimi C.N.; Shaffer C.M.; Müller C.; Sala C.; van Duijn C.M.; Saint-Pierre A.; Ackermann D.; Shriner D.; Ruggiero D.; Toniolo D.; Lu Y.; Cusi D.; Czamara D.; Ellinghaus D.; Siscovick D.S.; Ruderfer D.; Gieger C.; Grallert H.; Rochtchina E.; Atkinson E.J.; Holliday E.G.; Boerwinkle E.; Salvi E.; Bottinger E.P.; Murgia F.; Rivadeneira F.; Ernst F.; Kronenberg F.; Hu F.B.; Navis G.J.; Curhan G.C.; Ehret G.B.; Homuth G.; Coassin S.; Thun G.A.; Pistis G.; Gambaro G.; Malerba G.; Montgomery G.W.; Eiriksdottir G.; Jacobs G.; Li G.; Wichmann H.E.; Campbell H.; Schmidt H.; Wallaschofski H.; Völzke H.; Brenner H.; Kroemer H.K.; Kramer H.; Lin H.; Mateo Leach I.; Ford I.; Guessous I.; Rudan I.; Prokopenko I.; Borecki I.; Heid I.M.; Kolcic I.; Persico I.; Jukema J.W.; Wilson J.F.; Felix J.F.; Divers J.; Lambert J.C.; Stafford J.M.; Gaspoz J.M.; Smith J.A.; Faul J.D.; Wang J.J.; Ding J.; Hirschhorn J.N.; Attia J.; Whitfield J.B.; Chalmers J.; Viikari J.; Coresh J.; Denny J.C.; Karjalainen J.; Fernandes J.K.; Endlich K.; Butterbach K.; Keene K.L.; Lohman K.; Portas L.; Launer L.J.; Lyytikäinen L.P.; Yengo L.; Franke L.; Ferrucci L.; Rose L.M.; Kedenko L.; Rao M.; Struchalin M.; Kleber M.E.; Cavalieri M.; Haun M.; Cornelis M.C.; Ciullo M.; Pirastu M.; de Andrade M.; McEvoy M.A.; Woodward M.; Adam M.; Cocca M.; Nauck M.; Imboden M.; Waldenberger M.; Pruijm M.; Metzger M.; Stumvoll M.; Evans M.K.; Sale M.M.; Kähönen M.; Boban M.; Bochud M.; Rheinberger M.; Verweij N.; Bouatia-Naji N.; Martin N.G.; Hastie N.; Probst-Hensch N.; Soranzo N.; Devuyst O.; Raitakari O.; Gottesman O.; Franco O.H.; Polasek O.; Gasparini P.; Munroe P.B.; Ridker P.M.; Mitchell P.; Muntner P.; Meisinger C.; Smit J.H.; ICBP Consortium; AGEN Consortium; CARDIOGRAM; CHARGe-Heart Failure Group; ECHOGen Consortium; Kovacs P.; Kovacs P.; Wild P.S.; Froguel P.; Rettig R.; Mägi R.; Biffar R.; Schmidt R.; Middelberg R.P.; Carroll R.J.; Penninx B.W.; Scott R.J.; Katz R.; Sedaghat S.; Wild S.H.; Kardia S.L.; Ulivi S.; Hwang S.J.; Enroth S.; Kloiber S.; Trompet S.; Stengel B.; Hancock S.J.; Turner S.T.; Rosas S.E.; Stracke S.; Harris T.B.; Zeller T.; Zemunik T.; Lehtimäki T.; Illig T.; Aspelund T.; Nikopensius T.; Esko T.; Tanaka T.; Gyllensten U.; Völker U.; Emilsson V.; Vitart V.; Aalto V.; Gudnason V.; Chouraki V.; Chen W.M.; Igl W.; März W.; Koenig W.; Lieb W.; Loos R.J.; Liu Y.; Snieder H.; Pramstaller P.P.; Parsa A.; O'Connell J.R.; Susztak K.; Hamet P.; Tremblay J.; de Boer I.H.; Böger C.A.; Goessling W.; Chasman D.I.; Köttgen A.; Kao W.H.; Fox C.S.
Data(s)

2016
Resumo

Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways.
Identificador

http://serval.unil.ch/?id=serval:BIB_53B973F55248

isbn:2041-1723 (Electronic)

pmid:26831199

doi:10.1038/ncomms10023

http://my.unil.ch/serval/document/BIB_53B973F55248.pdf

http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_53B973F552486

isiid:000369032800001
Idioma(s)

en
Direitos

info:eu-repo/semantics/openAccess
Fonte

Nature Communications, vol. 7, pp. 10023
Tipo

info:eu-repo/semantics/article

article
Acesso ao item digital