Iron metabolism and incidence of metabolic syndrome.


Autoria(s): Kilani N.; Vollenweider P.; Waeber G.; Marques-Vidal P.
Data(s)

2015

Resumo

BACKGROUND AND AIMS: Whether iron metabolism affects metabolic syndrome (METS) is debated. We assessed the association between several markers of iron metabolism and incidence of METS. METHODS AND RESULTS: Data from 3271 participants (1870 women, 51.3 ± 10.4 years), free of METS at baseline and followed for 5.5 years. The association of serum iron, ferritin and transferrin with incident METS was assessed separately by gender. Incidence of METS was 22.6% in men and 16.5% in women (p < 0.001). After multivariate adjustment, a positive association was found between transferrin and incident METS in men: odds ratio (OR) and 95% confidence interval for the fourth relative to the first quartile 1.55 (1.04-2.31), p for trend = 0.03, while no association was found for iron OR = 0.81 (0.53-1.24), p for trend = 0.33 and ferritin OR = 1.30 (0.88-1.92), p for trend = 0.018. In women, a negative association was found between iron and incident METS: OR for the fourth relative to the first quartile 0.51 (0.33-0.80), p for trend<0.03; the association between transferrin and incident METS was borderline significant: OR = 1.45 (0.97-2.17), p for trend = 0.07 and no association was found for ferritin: OR = 1.11 (0.76-1.63), p for trend = 0.58. CONCLUSION: Transferrin, not ferritin, is independently associated with an increased risk of incident METS; the protective effect of iron in women should be further explored.

Identificador

http://serval.unil.ch/?id=serval:BIB_5872D6E93A9A

isbn:1590-3729 (Electronic)

pmid:26315622

doi:10.1016/j.numecd.2015.07.005

isiid:000364434000006

Idioma(s)

en

Fonte

Nutrition, Metabolism, and Cardiovascular Diseases, vol. 25, no. 11, pp. 1025-1032

Tipo

info:eu-repo/semantics/article

article