The ADO Index as a Predictor of Two-Year Mortality in General Practice-Based Chronic Obstructive Pulmonary Disease Cohorts.


Autoria(s): Abu Hussein N.; Ter Riet G.; Schoenenberger L.; Bridevaux P.O.; Chhajed P.N.; Fitting J.W.; Geiser T.; Jochmann A.; Joos Zellweger L.; Kohler M.; Maier S.; Miedinger D.; Schafroth Török S.; Scherr A.; Siebeling L.; Thurnheer R.; Tamm M.; Puhan M.A.; Leuppi J.D.
Data(s)

2014

Resumo

BACKGROUND: Existing prediction models for mortality in chronic obstructive pulmonary disease (COPD) patients have not yet been validated in primary care, which is where the majority of patients receive care. OBJECTIVES: Our aim was to validate the ADO (age, dyspnoea, airflow obstruction) index as a predictor of 2-year mortality in 2 general practice-based COPD cohorts. METHODS: Six hundred and forty-six patients with COPD with GOLD (Global Initiative for Chronic Obstructive Lung Disease) stages I-IV were enrolled by their general practitioners and followed for 2 years. The ADO regression equation was used to predict a 2-year risk of all-cause mortality in each patient and this risk was compared with the observed 2-year mortality. Discrimination and calibration were assessed as well as the strength of association between the 15-point ADO score and the observed 2-year all-cause mortality. RESULTS: Fifty-two (8.1%) patients died during the 2-year follow-up period. Discrimination with the ADO index was excellent with an area under the curve of 0.78 [95% confidence interval (CI) 0.71-0.84]. Overall, the predicted and observed risks matched well and visual inspection revealed no important differences between them across 10 risk classes (p = 0.68). The odds ratio for death per point increase according to the ADO index was 1.50 (95% CI 1.31-1.71). CONCLUSIONS: The ADO index showed excellent prediction properties in an out-of-population validation carried out in COPD patients from primary care settings. © 2014 S. Karger AG, Basel.

Identificador

http://serval.unil.ch/?id=serval:BIB_BDFF65EA48EA

isbn:1423-0356 (Electronic)

pmid:25115178

doi:10.1159/000363770

isiid:000342360800005

Idioma(s)

en

Fonte

Respiration, vol. 88, no. 3, pp. 208-214

Palavras-Chave #Chronic obstructive pulmonary disease; ADO index; Mortality prediction; Primary care
Tipo

info:eu-repo/semantics/article

article